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Joseph Calabrese has received federal funding from the Department of Defense, Health Resources Services Administration and National Institute of Mental Health.

In clinical trials, survival has been reported in acute overdoses of up to 30 grams of quetiapine.

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P450 3A4 isoenzyme is involved in the metabolism of quetiapine to its major, but inactive, sulfoxide metabolite and in the metabolism of its active metabolite N-desalkyl quetiapine.

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