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In a sensitivity analysis for adherence, which was adjusted for changes in hormone use after study entry and in which linear time-varying hazard-ratio models were used for the intervals before and after July 2002, corresponding to the announcement of trial results, we observed a decreasing trend in the hazard ratio in the hormone-therapy group ( Figure 3 Adherence-Adjusted Effects over Time of Estrogen plus Progestin on the Risk of Breast Cancer in the WHI Observational Study.
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